Personally, I am shocked that numerous executive powers and zealous health authorities have given the green light to the administration of the present COVID-19 vaccines to children and teenagers, although these compounds are still in an experimental stage and can have significantly controversial effects, both short and long-term. The evidence that children and youngsters are much less likely to develop morbidity and be admitted to hospital than adults is clear-cut, and likewise, I really do not understand their emergency to offer this substance to hundreds of millions of children all around the world.
The current approach is like fighting negativity using negativity due to the viral nature and origins
With regards to the mRNA technology used in these vaccines, the following needs to be mentioned: the mRNA is nucleoside-modified (that is, genetically modified, containing pseudouridine residues instead of natural uridine) in order to be more resistant to enzymes that degrade it after the translation process has finished. Moreover, the mRNA is also protected by lipid nanoparticles so the protection against RNA-degrading enzymes is stronger. The reason why scientists chose such an approach is that more than just a few spike proteins are intended to be synthesised, since the desired outcome of this is the development of a substantial immune response, with a rather lasting immune memory formed. The potential problem with this comes in two aspects: the location of the injection is an intramuscular site of the upper arm, and that site happens to be close to important blood vessels; the venae cavae, which transport blood straight to the heart. Now, since the mRNA is generally set to last from a few days to a few weeks, instead of a few hours, like natural mRNAs, the molecule is now capable of entering numerous cells, and consequently, binding numerous ribosomes and producing a higher number of spike protein copies.
Given that the spike protein has been shown to be cytotoxic, including for endothelial cells, which form the tissue on the wall of blood vessels, there is actually a risk of those spike protein copies breaking the endothelial barrier, entering the bloodstream and the lymphatic system, travel to various organs and cause blood clots in the process. Furthermore, the spike protein has showed to act as a superantigen in severe cases of COVID-19 that involve multi-systemic inflammation. Such characteristics of an antigen are not found even in the cases of SARS-CoV-1 and MERS-CoV. The magnitude of harm it causes immunologically is similar to the one of the staphylococcal enterotoxin B superantigen (Mary H. Cheng et al, 2020). A Salk Institute detailed study indicated that COVID-19 is not primarily a respiratory disease, but a blood-borne one, meaning that the virus and its spike protein affect the bloodstream the most. This would perfectly explain why the virus causes most of the time mild forms of disease when infecting the upper respiratory tract, and why the virus causes many times severe forms of disease, like multisystemic inflammation and blood clots when it crosses the alveolar barrier and enters important blood vessels. Also, the spike protein has been displaying toxicity to the aquatic environment. With regards to other effects upon human immunity, the spike protein stimulates pro-inflammatory immune responses through Toll-Like-Receptor 4 signalling. As a result, the pathogenic protein often affects the activity of macrophages and causes excessive inflammation. Thankfully, the immune system most of the time prevents the virus from entering the lungs and the bloodstream, which explains why most people only get mild disease and likewise, we support the evidence presented in the Great Barrington Declaration. We believe that the spike protein should be kept far from blood vessels, especially important ones, such as the venae cavae.
Furthermore, 2D static and 3D microfluidic in-vitro models showed that the spike protein is capable of crossing the blood-brain barrier and affecting various neuronal networks. Given that a significant number of people already suffered from various kinds of neurological damages post-vaccine, it is very likely that an unprecedented number of vaccine recipients will suffer from spike protein-induced brain damages that will be life-altering and irreversible, and that will include many children as well.
Given the Salk Institute evidence-based study, one must wonder, why are mainstream scientists strongly recommending an intramuscular administration of pathogenic proteins with displayed levels of toxicity to the endothelia and strong signs of viral and spike protein-induced pathogenesis in the circulatory system? Since the venae cavae lead straight to the heart, a considerable risk of myocarditis appears. The adenoviral vector-based vaccines do not lead to significantly different implications, since the adenoviral vectors are set to enter multiple cells and produce a similar number of spike protein copies. The only possible difference between the two vaccine types is that the spike proteins produced by the adenoviral vectors tend to be more soluble, and this would explain why blood clotting as an adverse event tends to be more prevalent in this case. The reason why it is much less often for a natural infection to lead to blood infection and systemic inflammation is the ability of the mucosal immunity in the nasopharynx to tackle the virus more efficiently.
Increased risks of myocarditis in children and young adults
The reason why risks of myocarditis are higher in children and young adults is the following: young people generally have more STEM cells in their organism than old people, and children have the highest number of these cells. A study published in December 2020 has shown that a small proportion of the SARS-CoV-2’s mRNA (including a small proportion of the sequence encoding the spike protein) is reverse transcribed by HIV-1/LINE-1 Reverse Transcriptases and then integrated by DNA Integrases into various regions of the coding and non-coding DNA of the host cell.
Does this matter? Well, the number of amino acid residues that form the polypeptide sequence of the spike protein is 1,273, meaning that the number of nucleotides in the spike protein-encoding mRNA is 3,829 nucleotides. From this, around 30-40 nucleotides will be reverse transcribed and integrated into various regions of the host cell’s genome. A few nucleotides may be inserted into important genes and change their reading frame, causing a few induced mutations. An additional issue is that there sometimes may be a few more nucleotides inserted into one DNA strand in the host cell’s genome than the nucleotides that were taken from the mRNA. This process of integration into the genome will happen in each cell the mRNA will manage to enter. The main concern of this situation is the possibility that the spike protein and its mRNA will reach multiple organs and likewise, enter multiple types of cells. In this case, the risk of LINE-1 Reverse Transcription-induced mutations is higher, and I believe scientists should study the extent of this problem. Given that LINE-1 Reverse Transcriptase activity may be associated with tumourigenesis, there may be a worst-case scenario, in which tumours will form. The difference between the intramuscular injection and natural infection is that the virus first enters sites where mucosal immunity is active and likewise, the virus will manage to infect multiple cell types less often and in the vast majority of cases only when the virus crosses the alveolar barrier to enter the bloodstream, infect nearby organs and cause multisystemic inflammation. In other words, it is less common for the pathogenic mRNA to enter multiple types of cells in the case of natural infection than in the case of the intramuscular vaccination using the present mRNA technology, especially in the case of children and young adults.
For now, let us use this reverse transcription phenomenon as a potential marker for a spike protein invasion of cells. The results of the study determined that inducible pluripotent STEM cells of the myocardium and the alveoli were most likely to have this reverse transcription and DNA integration phenomenon take place inside them. Likewise, there is a substantial probability that the STEM cells of the myocardium and the alveoli are the most susceptible to attack and damage by the spike protein. This possible event, combined with the fact that children and young adults generally have stronger Interferon I-based immunity and that the virus first infects areas where mucosal immunity is most active, would perfectly explain why the highest incidence of post-COVID-19 vaccine myocarditis is in children and young adults. One misconception that we will need to address is that health authorities will be using a single dose of the mRNA vaccine and that the dosage will be lower, and they will use this as a method to underestimate the risks. Even if a dose for children will only constitute a third of a dose used in adults, there will still be a significant amount of produced spike protein (for example, instead of 900,000 spike proteins, there will be 300,000 produced spike proteins, which is still a high amount). Given that younger children have a significantly lower BMI (body mass index) than adults, this means that a third of a dose would actually still be equivalent to a dose for adults. Overall, the risks are not substantially diminished, and the argument very likely remains more important than in the case of young adults aged 18-25.
Figure 1: The highest extent of reverse transcription and recombination with the genome of STEM cells in the myocardium and the alveoli (shown in section c) might indicate their highest susceptibility to attack by the spike protein (L. Zhang et al, 2020)
Even Dr. Fauci had once said that there was growing evidence that low-dose Interferon I drops are effective against AIDS, which is the disease of the century and yet, during the SARS-CoV-2 pandemic, the same governmental doctor in sciences first insisted there was no cure or significant treatment to COVID-19 and then that the only way to eventually get out of the pandemic was to introduce another significant amount of spike proteins inside the organism. Moreover, the spike protein has recently been demonstrated to be capable of entering the nucleus of cells and weakening genes implicated in DNA repair mechanisms (i.e. BRCA1 and TP53) and antibody gene rearrangement (i.e. 53BP1), thereby potentially causing a higher susceptibility to mutation and risks of the secretion of suboptimal antibodies, which will only help the virus adapt to such antibodies, mutate and modify its antigens without very significant complications.
Deduction offered objectively
Therefore, children and teenagers should never be offered such medical acts. Instead, researchers should come together and test a low-dose Interferon I-based nasal spray as a potential vaccine. Such a prophylactic intervention would best be given in a lower dosage to children than adults, in case it is proven to be successful. The risks of side effects are much lower and the agent would contain products of the human body that are the frontline carers of the immune system in case a pathogenic agent like SARS-CoV-2 ever enters the system. Such a nasal spray would possibly require administration anytime between the time when the first cases of infection happen within the local community to just two days after the onset of symptoms, just like Vitamin D3 and other therapeutic agents would require to be administered in the first stages of the disease in order to reach the desired results. A later administration of the nasal spray not only could not offer a significant improvement of the symptoms, but could also aggravate the disease and so, when, how and how much represent three essential factors that influence the effectiveness of this medical compound.
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